Top Ten Reexamination and Invalidation Cases

Interpreting the Stereochemistry of Phosphorus and Proving Commercial Success: How Gilead's Nucleoside Phosphoramidate Prodrug Patent "Captured" Sofosbuvir and Survived Invalidation

2026年11月9日

In pharmaceutical patent disputes, claim interpretation can be decisive because it defines the claimed subject matter against which novelty and inventive step are assessed. A single stereochemical notation in a structural formula may determine whether a patented claim covers a commercially successful drug worth billions of dollars. The dispute in the Gilead Sciences Inc. (hereinafter […]